APOBEC3B

Regulation of an Oncogene in Sickness and in Health

Pieter Roelofs • Boek • paperback

• Samenvatting
  Free download at https://doi.org/10.54195/9789465150628
  
  Cancer is characterized by a complex array of genomic mutations. These mutations are caused by a myriad of sources, such as UV-light, reactive compounds in cigarette smoke, or deficiencies in repair mechanisms. Mutations can also be brought about by several members of the APOBEC family of deaminases. Interestingly, under healthy circumstances these APOBEC proteins “serve to protect”, and, amongst others, introduce mutations in viral genomes and in LINE-1 elements. However, these proteins are largely agnostic to their substrate’s origin and can react with human genomic DNA, causing mutations in the cellular genomic code. Specifically, APOBEC3A and APOBEC3B contribute to the accumulation of genomic mutations in various cancers, including breast cancer. The high mutational burden associated with APOBEC-activity throws a grim shadow at traditional anti-cancer treatments, highlighting the importance of a better understanding of APOBEC-associated mutagenesis and the innovation of existing treatment regiments. As part of this endeavor, this thesis focusses on elucidating the transcriptional activation of the APOBEC3B oncogene and, to a lesser extent, that of APOBEC3A. It also reviews several clinical aspects surrounding APOBEC-mediated mutagenesis.
• Productinformatie
  Binding : Paperback
  Distributievorm : Boek (print, druk)
  Formaat : 170mm x 240mm
  Aantal pagina's : 174
  Uitgeverij : Radboud University Press
  ISBN : 9789465150628
  Datum publicatie : 03-2025
  
• Inhoudsopgave
  niet beschikbaar
• Reviews (0 uit 0 reviews)
  Wil je meer weten over hoe reviews worden verzameld? Lees onze uitleg hier.