Hit the brakes

Unraveling oscillatory dynamics during reactive stopping in freely behaving rats

Jordi ter Horst • Boek • paperback

• Samenvatting
  Free download at https://doi.org/10.54195/9789465150642
  
  The overarching goal of this dissertation was to better understand the underlying neural oscillatory mechanisms of reactive stopping in the hyperdirect pathway, by making use of dual-area, multi-electrode recordings in rats performing a multi-session stop-signal task. The first aim was to optimize the rodent stop-signal task design, the second aim was to find out whether within-animal varying stopping speeds were statistically meaningful, and the third, major aim was to establish an electrophysiological rodent model with high temporal and anatomical precision to learn about the oscillatory mechanisms of reactive stopping in the orbitofrontal cortex (OFC) and subthalamic nucleus (STN), two key areas of the hyperdirect pathway. Altogether, we can conclude from this dissertation that the field might need revision on two stopping themes: 1) stopping speed is a state-like, and not trait-like, characteristic that meaningfully changes from time to time, and 2) rather than increased beta-band activity in the hyperdirect pathway, reactive stopping seems to be facilitated by decreased local beta-band activity and interareal synchronization.
• Productinformatie
  Binding : Paperback
  Distributievorm : Boek (print, druk)
  Formaat : 170mm x 240mm
  Aantal pagina's : 121
  Uitgeverij : Radboud University Press
  ISBN : 9789465150642
  Datum publicatie : 04-2025
  
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