Mechanism behind clinical symptoms in cerebral small vessel disease

Hao Li • Boek • paperback

• Samenvatting
  Free download at https://doi.org/[10.54195/9789465152073]
  
  Cerebral small vessel disease (SVD) affects the brain’s small vessels and is a major cause of vascular cognitive impairment and dementia. Conventional MRI markers such as white matter hyper-intensities (WMH), lacunes, and micro-bleeds capture only part of the underlying pathology, failing to explain the marked heterogeneity in clinical symptoms among patients. This thesis applies advanced multi-modal neuroimaging, particularly diffusion imaging, to uncover mechanisms linking SVD damage to clinical manifestations. Three major mechanisms are explored: (1) strategic effects, focusing on damage to the thalamus and dopaminergic and cholinergic white-matter pathways; (2) remote effects, reflecting secondary neurodegeneration related to focal lesions like WMH and cortical microinfarcts (CMIs); and (3) waste-clearance dysfunction, involving perivascular pathways, choroid plexus, and deep medullary veins. By integrating these imaging markers with cognitive and clinical data, this work elucidates multi-level pathways through which SVD disrupts brain structure, providing insights for future diagnostic and therapeutic strategies.
• Productinformatie
  Binding : Paperback
  Distributievorm : Boek (print, druk)
  Formaat : 170mm x 240mm
  Aantal pagina's : 319
  Uitgeverij : Radboud University Press
  ISBN : 9789465152073
  Datum publicatie : 12-2025
  
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