Mimicking the Regenerative Matrix

Bioactive Scaffolds to Improve Skin Repair

Nancy Avila-Martinez • Boek • paperback

• Samenvatting
  Free download at https://doi.org/10.54195/9789465151564
  
  Severe deep skin wounds, such as burns, often heal with scars that contract, limiting mobility and quality of life. Current dermal templates are unable to prevent these complications. This thesis describes the development of new biomaterials inspired by species whose skin heals without scarring. Three prototypes were designed by enriching type I collagen matrices with proteins, chains of disaccharides (glycosaminoglycans), and effector molecules: extracellular matrix components that play key roles in natural regeneration. The tests showed encouraging results: reduced expression of scarring-related genes, activation of pro-healing cells, and less wound contraction. These outcomes demonstrate that biomaterials tailored with regenerative cues can improve healing compared to existing therapies. This work contributes innovative strategies for wound care, aimed at restoring function, preventing contractures, and improving the long-term recovery of patients with severe injuries.
• Productinformatie
  Binding : Paperback
  Distributievorm : Boek (print, druk)
  Formaat : 170mm x 240mm
  Aantal pagina's : 209
  Uitgeverij : Radboud University Press
  ISBN : 9789465151564
  Datum publicatie : 10-2025
  
• Inhoudsopgave
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