Opportunities in optimizing cytotoxic treatment of lung cancer in the era of immunotherapy

Mart Pepijn Kicken • Boek • paperback

• Samenvatting
  Free download at https://doi.org/10.54195/9789465151434
  
  Based on the findings of this thesis, a series of evidence-based recommendations are proposed to optimize and personalize the dosing of carboplatin, pemetrexed, docetaxel, and atezolizumab in the treatment of advanced non-small cell lung cancer (NSCLC) patients..
  
  For carboplatin, it is recommended to adopt cystatin C-based estimation of drug clearance. This approach incorporates patient-specific parameters including age, sex, body weight, and serum creatinine, and has shown superior accuracy and precision compared to traditional creatinine-based formulas like the Cockcroft-Gault formula in multiple prospective studies.
  
  For pemetrexed, standard dosing poses a high risk of toxicity in patients with impaired renal function (GFR
• Productinformatie
  Binding : Paperback
  Distributievorm : Boek (print, druk)
  Formaat : 170mm x 240mm
  Aantal pagina's : 247
  Uitgeverij : Radboud University Press
  ISBN : 9789465151434
  Datum publicatie : 10-2025
  
• Inhoudsopgave
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