Schema Driven Memory Consolidation

A Neurobiological Investigation Using the HexMaze Paradigm

Alejandra Alonso • Boek • paperback

• Samenvatting
  Free download at https://doi.org/10.54195/9789465150598
  
  This thesis investigates the neurobiology of schemas in memory consolidation, focusing on how prior knowledge facilitates learning. Using the mouse HexMaze—a task designed to study spatial and schema-based memory—three distinct learning phases were identified, showing that memory development depends more on elapsed time than experience frequency.
  
  A gradient schema theory is proposed, suggesting that hippocampal involvement in memory decreases as prior knowledge increases, shifting memory processes to cortical regions. Pharmacological and molecular experiments revealed that hippocampal, prelimbic, and retrosplenial cortices form a distributed memory network, with dynamic contributions during schema formation and retrieval.
  Findings emphasize the flexibility and efficiency of schema-based learning, where extensive prior knowledge enables rapid cortical consolidation. This work underscores the importance of schemas in memory and demonstrates the HexMaze as a powerful tool for studying complex learning processes in rodents.
• Productinformatie
  Binding : Paperback
  Distributievorm : Boek (print, druk)
  Formaat : 170mm x 240mm
  Aantal pagina's : 250
  Uitgeverij : Radboud University Press
  ISBN : 9789465150598
  Datum publicatie : 03-2025
  
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