Unraveling the Genetic Architecture of Pain

Exploring the genetic factors contributing to rare/multifactorial pain disorder and pain treatment outcome

Song Li • Boek • paperback

• Samenvatting
  Free download at https://doi.org/10.54195/9789465150772
  
  Pain, a complex sensory and emotional experience, can result from Mendelian genetic disorders or multifactorial conditions, such as chronic pain. Chronic pain affects around 20% of adults and is a major contributor to global disability. This thesis explores the genetic basis of both Mendelian and multifactorial pain conditions. We investigated erythermalgia (EM), a rare Mendelian pain disorder, using whole-genome sequencing in two families. While no definitive pathogenic variants were found, several candidate genes were identified, emphasizing the need for broader collaboration and refined phenotyping. For multifactorial pain, genome-wide association studies (GWAS) revealed multiple loci linked to chronic postsurgical pain (CPSP), including novel associations with GLRA3 and PDE4D. Further, a protocol for a large-scale prospective study was outlined to predict postoperative pain based on genetic and clinical data. Additionally, we identified a genetic locus associated with treatment response in musculoskeletal pain, with implications for personalized pharmacological strategies. Overall, this work underscores the contribution of genetic factors—particularly neurological and immunological pathways—to pain development and management, offering a foundation for precision medicine approaches in pain care.
• Productinformatie
  Binding : Paperback
  Distributievorm : Boek (print, druk)
  Formaat : 170mm x 240mm
  Aantal pagina's : 377
  Uitgeverij : Radboud University Press
  ISBN : 9789465150772
  Datum publicatie : 09-2025
  
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